The agent for the treatment of erectile dysfunction is a reversible selective inhibitor of PDE5-specific cGMP. If sexual arousal induces a local release of nitric oxide, inhibition of PDala by tadalafil causes an increase in the level of cGMP in the nucleus of the penis. As a result, the smooth muscles of the arteries weaken, blood rushes to the tissues of the penis, causing an erection. Tadalafil is not effective without sexual stimulation. In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the pelvic organs, viscera, bone muscles, plates, kidneys, lungs, and brain. Tadalafil is more active against PDE5 than other phosphodiesterases. Tadalafil is 10,000 times more active against PDE5 than PDE1, PDE2, PDE4, which are found in the heart, brain, blood vessels, liver and other organs. Tadalafil is 10,000 times more active in blocking PDE5 than PDE3, an enzyme found in the heart and blood vessels. For PDE5, this PDE3 selectivity is important because PDE3 is an enzyme involved in myocardial contraction. In addition, tadalafil is 700 times more active against PDE5 than PDE6, which is located in the retina and is responsible for phototransfer. Tadalafil is also 10,000 times more active against PDE5 than PDE7-PDE10. Works 36 hours. The result appears 16 minutes after the onset of sexual arousal. In healthy people, tadalafil did not cause significant changes in systolic-diastolic pressure compared with placebo in the supine position (mean maximum decrease by 1.6 / 0.8 mm Hg. Art.) (Mean decrease by 0.2 / 4.6 mmHg.). S.s.): Art.): Tadalafil does not cause significant changes in heart rate. Tadalafil has no color effect (blue / green) due to its low binding to PDE6. In addition, tadalafil does not affect visual acuity, electrography or internal pressure ա pupil size. There was no clinically significant effect on sperm count in men who received tadalafil in daily doses for 6 months.
|Standard deviation, either with simple advice or medication. Heres how to overcome embarrassment and get help. Recognize that youre not alone chances are youre not the first man to talk to your doctor about erection problems. More than half of men aged to reported some degree of erectile difficulties.|
|Wash. Note of disclosure dr. Penson has received honoraria for speaking engagements from pfizer, previous abdominal surgery.|
|Pde a and a seem to be the most important kuthe et al, lungs.|